منابع مشابه
The challenges of replication
Interpreting the first results from the Reproducibility Project: Cancer Biology requires a highly nuanced approach.
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Wireless and mobile communication is an important technology that improves user’s daily life and facilitates the development of some new technology such as electronic commerce and mobile commerce. Replication is a fundamental technique for supporting concurrent work practices in mobile environments. Optimistic replication algorithms allow replica contents to become stale but in a controlled way...
متن کاملChromatin Challenges during DNA Replication and Repair
Inheritance and maintenance of the DNA sequence and its organization into chromatin are central for eukaryotic life. To orchestrate DNA-replication and -repair processes in the context of chromatin is a challenge, both in terms of accessibility and maintenance of chromatin organization. To meet the challenge of maintenance, cells have evolved efficient nucleosome-assembly pathways and chromatin...
متن کاملThe Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication
Eukaryotic cells must accurately and efficiently duplicate their genomes during each round of the cell cycle. Multiple linear chromosomes, an abundance of regulatory elements, and chromosome packaging are all challenges that the eukaryotic DNA replication machinery must successfully overcome. The replication machinery, the "replisome" complex, is composed of many specialized proteins with funct...
متن کاملChromatin challenges during DNA replication: a systems representation.
In a recent review, A. Groth and coworkers presented a comprehensive account of nucleosome disassembly in front of a DNA replication fork, assembly behind the replication fork, and the copying of epigenetic information onto the replicated chromatin. Understanding those processes however would be enhanced by a comprehensive graphical depiction analogous to a circuit diagram. Accordingly, we have...
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ژورنال
عنوان ژورنال: Science
سال: 2019
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aaz2701